He & She MD NAD+ Review 2026: $149/mo
Updated: August 12, 2026 · By Charly P. · Reviewed by Ved P. · Not a medical review · 8 min read
He & She MD is a modern telehealth clinic whose Longevity line does something almost no other NAD+ provider does: it sells the same therapy in three delivery formats — a subcutaneous injection, a topical NAD+ cream, and a nasal spray — all at a single flat price of $149/month on a 12-month supply. Most platforms make you pick between an injection and a nasal spray; the cream is a genuinely unusual needle-free option. With no membership fee, no hidden costs, free shipping, board-certified providers, and unlimited provider messaging, He & She MD is our #2 pick on our best NAD+ treatments 2026 list for people who want format flexibility without pricing games.
Quick Verdict
| Our Rating | #2 Ranked — Best for Format Flexibility |
|---|---|
| Best For | People who want a choice of injection, cream, or nasal spray at one flat price |
| Starting Price | $149/mo (12-month supply) |
| Delivery Formats | Injection + topical cream + nasal spray |
| Shipping | Free, expedited, every order |
| Membership Fees | None |
| Hidden Fees | None |
| Insurance Required | No |
| Medical Oversight | Board-certified U.S. providers |
| Pharmacy | Licensed, FDA-regulated U.S. pharmacies |
| Ongoing Care | Unlimited provider messaging for the life of your plan |
| In-Person Visits | None required |
What Is He & She MD?
He & She MD is a modern telehealth clinic offering treatments across Weight Loss, Longevity, Hormone Therapy, Performance, Hair Growth, and Sexual Health. Its Longevity line centers on NAD+ therapy, delivered entirely online.
| Flow | 5-minute intake quiz → licensed U.S. physician or DO reviews → medication ships if appropriate |
|---|---|
| No | In-person visits, insurance hoops, or membership fee |
| Format breadth | Subcutaneous injection, topical cream, and nasal spray — each $149/month on a 12-month supply |
Compared with bmiMD (competes purely on price) or Enhanced.com (our top-ranked provider, leads on personalized dosing), He & She MD's edge is giving needle-averse patients two credible needle-free routes rather than one.
What Sets It Apart
- ✓Injection, topical cream and nasal spray
- ✓Flat $149/mo on a 12-month supply ($1,788/yr)
- ✓No membership fee or hidden costs
- ✓Free, expedited shipping on every order
- ✓Board-certified U.S. providers review every intake
- ✓Unlimited provider messaging
- ✓FDA-regulated licensed U.S. pharmacies
- ✓Fully online, no in-person visits
NAD+ and Brain Fog
Ask why someone bought NAD+ and “mental clarity” comes up more than anything else, so it's worth looking at that claim directly:
- The mechanistic case is genuine. A Cell Metabolism review of NAD+ in brain aging ties NAD+ to neuronal energy and mitochondrial health; levels fall with age.
- The outcome trials were sobering. NAD+ levels rose on high-dose precursors, but cognitive scores did not beat placebo. Clinical benefit is not yet demonstrated.
Anyone selling you NAD+ for brain fog — He & She MD included — is selling a plausible hypothesis, not a proven treatment, and you should price your expectations to that.
What He & She MD does control is friction. Three formats — injection, nasal spray and topical cream — mean a daily routine you might actually keep for the eight to twelve weeks it would take to find out whether you are a responder:
- ✓Injection: highest bioavailability, weekly needle
- ✓Nasal spray: needle-free, easiest to travel with
- ✓Topical cream: easiest daily option for non-injectors
- ✓One $149/mo price covers any format
How He & She MD Works
Getting started with He & She MD is entirely online:
- 1.Take the Quiz
Quick questions on goals, symptoms and history; about 5 minutes.
- 2.Medical Review
A board-certified provider prescribes only if you are eligible.
- 3.Choose Your Format
Injection, cream or nasal spray, based on guidance and comfort.
- 4.Free Home Delivery
Free expedited shipping, plus unlimited provider messaging.
He & She MD Pricing
He & She MD keeps pricing simple: every NAD+ format is the same flat rate, so your choice is about delivery method, not budget.
| NAD+ Injection | $149/mo (12-month supply) |
|---|---|
| NAD+ Cream | $149/mo (12-month supply) |
| NAD+ Nasal Spray | $149/mo (12-month supply) |
| Annual Total | $1,788/yr |
| Shipping | Free, expedited, every order |
| Membership Fees | None |
| Hidden Fees | None |
| Insurance Required | No |
| Ongoing Care | Unlimited provider messaging for the life of your plan |
At $149/mo, He & She MD sits in the middle of the market — above budget leaders like bmiMD ($89/mo) but well below premium tiers that can run $199–$299/mo. What you pay the difference for is format choice and included ongoing care. See how every option stacks up on our full NAD+ provider comparison.
He & She MD vs. Others
| Factor | He & She MD | Typical Competitor |
|---|---|---|
| Starting price | $149/mo (12-mo supply) | $89–$299/mo |
| Delivery formats | Injection + cream + nasal spray | Injection only or injection + nasal |
| Flat price across formats | Yes | Rarely |
| Free shipping | Yes, expedited | Varies |
| Membership fees | None | Varies |
| Ongoing messaging | Unlimited, included | Often limited or extra |
| Medical oversight | Board-certified U.S. providers | Varies |
| Pharmacy | FDA-regulated U.S. pharmacies | Varies |
| Insurance required | No | Varies |
Pros & Cons
Pros
- ✓Injection, cream and nasal spray formats
- ✓Two rare needle-free options
- ✓One flat $149/mo price for every format
- ✓No membership fee or hidden costs
- ✓Free, expedited shipping on every order
- ✓Board-certified providers, FDA-regulated pharmacies
- ✓Unlimited provider messaging
- ✓No in-person visits required
Cons
- ✗Compounded, not an FDA-approved finished drug
- ✗$149/mo requires a 12-month supply
- ✗Priced above budget injectable providers
Is He & She MD Right for You?
Great fit if you
- ✓Want injection, cream or nasal spray options
- ✓Dislike needles and want several alternatives
- ✓Value flat pricing, no membership or hidden fees
- ✓Want board-certified oversight and unlimited messaging
- ✓Prefer free, expedited shipping
- ✓Have fatigue, brain fog or signs of aging
Not ideal if you
- ✗Want the lowest injectable NAD+ price
- ✗Prefer month-to-month, no supply commitment
- ✗Need a brand-name (non-compounded) product
For patients who care most about how their NAD+ is delivered — and want a legitimate needle-free path — He & She MD is one of the most flexible options available. If price is your only priority, compare it against DirectMeds and the rest of our ranked NAD+ providers before you decide.
He & She MD FAQ
Recommended Providers
Our editorial team’s top picks for this category.
Safety Information
NAD+ therapy is generally well tolerated:
- Provider-reviewed intake before any prescription; clinical services by Wasef Health, PC.
- Dispensed by FDA-registered U.S. pharmacies, incl. Jungle Jim’s Pharmacy and GoGoMeds.
- Compounded NAD+ is not FDA-approved but legal when prescribed; see FDA guidance on drug compounding.
- Common early effects: mild warmth or flushing.
Our Editorial Take
He & She MD's pitch is format freedom, and it delivers on it more completely than almost anyone in the category. Offering an injection, a topical cream, and a nasal spray — all at the same $149/month — means a needle-averse patient never has to trade quality for comfort, and a committed injector still gets the highest-bioavailability route. The flat pricing removes the usual upsell maze, and the included unlimited provider messaging is the kind of ongoing-care detail that budget platforms tend to strip out.
It isn't the cheapest injectable NAD+ on our list, and the best rate assumes a 12-month supply. But for the patient whose main question is “how do I want to take this?” rather than “what's the rock-bottom price?”, He & She MD is one of the most sensible, transparent choices in the market.
Final Verdict
He & She MD is our #2-ranked NAD+ provider, and our top pick for format flexibility and transparent pricing. At $149/mo across injection, cream, and nasal spray — with free shipping, board-certified oversight, FDA-regulated pharmacies, and unlimited provider messaging — it's the clearest choice for patients who want to control how their NAD+ is delivered without paying premium prices or wrestling with hidden fees.
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Medical Disclaimer: The content on this site is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider for medical questions, treatment decisions, or emergency care. Do not disregard professional medical advice or delay seeking it based on information found here.