He & She MD NAD+ Review 2026: Injection, Cream & Nasal Spray at $149/mo
Published: July 31, 2026 · By Charly P. · 8 min read
He & She MD is a modern telehealth clinic whose Longevity line does something almost no other NAD+ provider does: it sells the same therapy in three delivery formats — a subcutaneous injection, a topical NAD+ cream, and a nasal spray — all at a single flat price of $149/month on a 12-month supply. Most platforms make you pick between an injection and a nasal spray; the cream is a genuinely unusual needle-free option. With no membership fee, no hidden costs, HSA/FSA accepted, free shipping, board-certified providers, and unlimited provider messaging, He & She MD is our #1 pick on our best NAD+ treatments 2026 list for people who want format flexibility without pricing games.
Quick Verdict: He & She MD NAD+ at a Glance
| Our Rating | #1 Ranked — Best NAD+ Provider |
|---|---|
| Best For | People who want a choice of injection, cream, or nasal spray at one flat price |
| Starting Price | $149/mo (12-month supply) |
| Delivery Formats | Injection + topical cream + nasal spray |
| Shipping | Free, expedited, every order |
| Membership Fees | None |
| Hidden Fees | None |
| Insurance Required | No |
| Medical Oversight | Board-certified U.S. providers |
| Pharmacy | Licensed, FDA-regulated U.S. pharmacies |
| Ongoing Care | Unlimited provider messaging for the life of your plan |
| In-Person Visits | None required |
What Is He & She MD?
He & She MD is a modern telehealth clinic offering treatments across Weight Loss, Longevity, Hormone Therapy, Performance, Hair Growth, and Sexual Health. Its Longevity line centers on NAD+ therapy, delivered entirely online: you complete a 5-minute intake quiz, a licensed U.S. physician or DO reviews your intake, and — if appropriate — your medication ships discreetly to your door. There are no in-person visits, no insurance hoops, and no membership fee. HSA/FSA cards are accepted.
What sets He & She MD apart in the NAD+ category is format breadth. Their program includes a subcutaneous NAD+ injection, a topical NAD+ cream, and a NAD+ nasal spray, each priced at $149/month on a 12-month supply. Compared with bmiMD, which competes purely on price, or Enhanced.com, our top-ranked provider that leads on personalized dosing, He & She MD's edge is giving needle-averse patients two credible needle-free routes rather than one.
What Makes He & She MD Stand Out
- ✓Three NAD+ delivery formats — injection, topical cream, and nasal spray
- ✓Single flat price of $149/mo across all formats, locked on a 12-month supply ($1,788/yr)
- ✓No membership fee, no hidden costs, HSA/FSA accepted
- ✓Free, expedited shipping on every order
- ✓Board-certified U.S. providers review every intake
- ✓Unlimited provider messaging for the life of your plan
- ✓FDA-regulated licensed U.S. dispensing pharmacies
- ✓Fully online — no in-person visits required
Why NAD+ Therapy Works — The Science
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every cell of the human body. It drives mitochondrial energy production, DNA damage repair, and the activation of longevity-related proteins called sirtuins. NAD+ levels decline with age, a trend researchers associate with fatigue, brain fog, slower metabolism, and accelerated cellular aging. According to NIH research, NAD+ is a critical cofactor for cellular energy metabolism and the longevity pathways that keep cells resilient.
Injectable and nasal spray NAD+ — like the formats in He & She MD's program — bypass the digestive system and reach higher bioavailability than oral supplements. The topical cream targets local delivery for patients who want a low-friction, needle-free daily routine.
- ✓Boost metabolism — supports cells in burning fuel more efficiently
- ✓Increase energy — recharges mitochondria for steadier daily stamina
- ✓Recover faster — supports muscle repair and reduces post-workout soreness
- ✓Sharper focus — supports neurotransmitter activity for clearer thinking
- ✓Age gracefully — promotes cellular repair and reduces oxidative stress
- ✓DNA repair — supports PARP enzymes and sirtuins tied to cellular longevity
How He & She MD Works — Step by Step
Getting started with He & She MD is entirely online:
- 1.Take the Quiz
Answer a few quick questions about your goals, symptoms, and history so your treatment can be personalized. The intake takes about 5 minutes.
- 2.Medical Review
A licensed, board-certified provider reviews your intake and prescribes treatment if you are eligible. If you are not a candidate, you are not prescribed treatment.
- 3.Choose Your Format
Select the NAD+ injection, topical cream, or nasal spray based on your provider's guidance and your own comfort with needles.
- 4.Free Delivery to Your Door
Once you are approved, a licensed pharmacy partner ships your medication free with expedited delivery, and you keep unlimited provider messaging for as long as you are on the program.
He & She MD NAD+ Pricing — Full Cost Breakdown
He & She MD keeps pricing simple: every NAD+ format is the same flat rate, so your choice is about delivery method, not budget.
| NAD+ Injection | $149/mo (12-month supply) |
|---|---|
| NAD+ Cream | $149/mo (12-month supply) |
| NAD+ Nasal Spray | $149/mo (12-month supply) |
| Annual Total | $1,788/yr |
| Shipping | Free, expedited, every order |
| Membership Fees | None |
| Hidden Fees | None |
| Insurance Required | No |
| Ongoing Care | Unlimited provider messaging for the life of your plan |
At $149/mo, He & She MD sits in the middle of the market — above budget leaders like bmiMD ($89/mo) but well below premium tiers that can run $199–$299/mo. What you pay the difference for is format choice and included ongoing care. See how every option stacks up on our full NAD+ provider comparison.
He & She MD vs. Other NAD+ Providers
| Factor | He & She MD | Typical Competitor |
|---|---|---|
| Starting price | $149/mo (12-mo supply) | $89–$299/mo |
| Delivery formats | Injection + cream + nasal spray | Injection only or injection + nasal |
| Flat price across formats | Yes | Rarely |
| Free shipping | Yes, expedited | Varies |
| Membership fees | None | Varies |
| Ongoing messaging | Unlimited, included | Often limited or extra |
| Medical oversight | Board-certified U.S. providers | Varies |
| Pharmacy | FDA-regulated U.S. pharmacies | Varies |
| Insurance required | No | Varies |
He & She MD NAD+ Pros & Cons — Honest Assessment
Pros
- ✓Three delivery formats — injection, cream, and nasal spray
- ✓Two needle-free options (cream and nasal spray), rare in this market
- ✓One flat $149/mo price across every format
- ✓No membership fee, no hidden costs, HSA/FSA accepted
- ✓Free, expedited shipping on every order
- ✓Board-certified providers and FDA-regulated dispensing pharmacies
- ✓Unlimited provider messaging for ongoing care
- ✓No in-person visits required
Cons
- ✗Compounded NAD+ — not an FDA-approved finished drug product
- ✗The $149/mo rate is tied to a 12-month supply commitment
- ✗Priced above budget-leading injectable NAD+ providers
Is He & She MD NAD+ Right for You?
He & She MD is a great fit if you
- ✓Want a choice of injection, topical cream, or nasal spray
- ✓Are needle-averse and want more than one needle-free route
- ✓Value flat, transparent pricing with no membership or hidden fees
- ✓Want board-certified oversight and unlimited provider messaging
- ✓Prefer free, expedited shipping straight to your door
- ✓Are experiencing fatigue, brain fog, or signs of aging
He & She MD may not be the best fit if you
- ✗Want the absolute lowest injectable NAD+ price on the market
- ✗Prefer month-to-month with no longer-term supply commitment
- ✗Need a brand-name (non-compounded) pharmaceutical product
For patients who care most about how their NAD+ is delivered — and want a legitimate needle-free path — He & She MD is one of the most flexible options available. If price is your only priority, compare it against DirectMeds and the rest of our ranked NAD+ providers before you decide.
Frequently Asked Questions About He & She MD NAD+
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Safety Information
NAD+ therapy is generally well tolerated. He & She MD requires every patient to complete a health intake reviewed by a licensed, board-certified U.S. provider before any prescription is issued. Medication is dispensed by licensed U.S. pharmacies that meet FDA regulatory standards; compounded medications such as NAD+ are not individually FDA-approved but are legal when prescribed by a licensed clinician. You can review the FDA's guidance on drug compounding for more context. Common early effects of NAD+ may include mild warmth or flushing.
Our Editorial Take
He & She MD's pitch is format freedom, and it delivers on it more completely than almost anyone in the category. Offering an injection, a topical cream, and a nasal spray — all at the same $149/month — means a needle-averse patient never has to trade quality for comfort, and a committed injector still gets the highest-bioavailability route. The flat pricing removes the usual upsell maze, and the included unlimited provider messaging is the kind of ongoing-care detail that budget platforms tend to strip out.
It isn't the cheapest injectable NAD+ on our list, and the best rate assumes a 12-month supply. But for the patient whose main question is “how do I want to take this?” rather than “what's the rock-bottom price?”, He & She MD is one of the most sensible, transparent choices in the market.
Final Verdict
He & She MD is our #1-ranked NAD+ provider for format flexibility and transparent pricing. At $149/mo across injection, cream, and nasal spray — with free shipping, board-certified oversight, FDA-regulated pharmacies, and unlimited provider messaging — it's the clearest choice for patients who want to control how their NAD+ is delivered without paying premium prices or wrestling with hidden fees.
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Medical Disclaimer: The content on this site is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider for medical questions, treatment decisions, or emergency care. Do not disregard professional medical advice or delay seeking it based on information found here.