Best Online Weight Loss Programs of 2026
Limited Offer: Semaglutide $89 | Tirzepatide $149
Lifetime price lock. GLP-1 from $149/mo. 100k+ customers.
Semaglutide $155/mo · needle-free tablet option
02
TrimRx
Excellent
Lifetime price lock. GLP-1 from $149/mo. 100k+ customers.
- Starting at $149/month, GLP-1 & GLP-1+GIP in stock
- Lifetime price lock — same price, every dose, no hidden fees
- Free shipping, arrives in 1–2 days · 100k+ happy customers
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Best Overall Pick
Which Weight Loss Approach Is Right for Me?
Every programme on this page prescribes GLP-1 medication under clinician supervision. What differs is whether it is compounded or branded, which molecule you get, how much coaching comes with it, and what a month costs. Settling how much support you want — a full structured programme or a low-cost prescription — usually narrows the list. Whether a GLP-1 is appropriate for you is a question for a licensed clinician who has your full medical history.
Low-cost compounded GLP-1
Compounded semaglutide or tirzepatide at the lowest monthly prices, for people prioritising cost who are comfortable with a pharmacy-compounded medication under a prescription.
On this page: Sunlight from $88/month, altRx from $89, and LTTL from $129 with flat pricing anchor the value end.
Structured, supported programmes
The medication is one part of a broader plan with coaching, check-ins and habit support, for people who want more than a prescription in the mail.
On this page: Found builds weight loss around your biology with support; Start Willow runs a structured programme from $249/month.
Established-brand onboarding
A recognised telehealth brand with a smooth start and a low entry price, for people who want a familiar name and a polished experience behind their care.
On this page: Ro offers a $39 start on its established platform; TrimRx and MedVi bring recognisable brands with promotional pricing.
Both molecules, your choice
Programmes that carry both semaglutide and tirzepatide, so your clinician can match the molecule to your history and budget without you switching provider.
On this page: altRx, BetterMe Rx and Lemonaid Health each offer both semaglutide and tirzepatide options.
GLP-1s are prescription medications, not shortcuts
Semaglutide and tirzepatide are clinically established for weight management at therapeutic doses, but they carry real considerations and are not appropriate for everyone, including people with a personal or family history of medullary thyroid cancer, MEN 2, or pancreatitis. Compounded versions are not FDA-reviewed. No provider on this page can tell you what it will do for you — disclose your full medical history at intake and speak to your own doctor first.
How We Evaluate Weight Loss Providers
Our comparison is a documentary review of what each provider publishes, checked against its own site. We do not run clinical trials, we do not test medication, and we do not collect patient outcome data — so you will not find efficacy scores, success rates or survey results anywhere on this page.
Compounded vs branded
Whether you are getting an FDA-approved branded product or a compounded GLP-1 prepared against your prescription — and which pharmacy prepares a compounded medication.
What the price includes
Whether the medication is inside the monthly figure or billed separately, and what the ongoing price is once any introductory or promotional offer ends.
Clinician oversight
Whether a licensed clinician reviews your intake, can adjust the dose as side effects appear, and is reachable between refills — not just at sign-up.
Molecule choice
Whether both semaglutide and tirzepatide are available, so the medication can be matched to your history and budget rather than the one the programme happens to stock.
Coaching and follow-up
Whether the plan includes coaching, structured check-ins and support for the GI side effects that come with dose increases, or is medication and little else.
Commitment and cancellation
Plan length, whether a membership fee sits on top of the medication, and how cancellation actually works.
Editorial scores and reader vote counts shown on the cards reflect ExploreTreatments’ own assessment and the votes cast on our weight loss pages. They are not clinical ratings, and they are not a measure of medical effectiveness. Provider details change frequently — always confirm current pricing and terms on the provider’s own site before you buy.
The Complete Guide to Online Weight Loss in 2026
How GLP-1 weight loss works
GLP-1 receptor agonists regulate appetite and slow stomach emptying, which for many people means eating less without white-knuckling it. The class is well established: the FDA approves specific semaglutide and tirzepatide products for chronic weight management. What the programmes on this page differ on is the medication type, the molecule, the support, and the price.
Semaglutide vs tirzepatide
Semaglutide is a GLP-1 agonist; tirzepatide adds GIP activity, and in trials it produced greater average weight loss — at a higher cost. Most programmes here carry both, so the choice is about budget and how your clinician reads your history. Our semaglutide vs tirzepatide guide covers the trade-offs, and the GLP-1 side effects guide covers what to expect as you titrate up.
Compounded vs branded GLP-1
Branded products (Wegovy, Zepbound) are FDA-approved but often expensive or supply-constrained. Compounded GLP-1 is prepared by a licensed pharmacy against your prescription and is usually cheaper — but, as the FDA notes for compounded drugs generally, it is not reviewed for safety or effectiveness before it reaches patients. Our compounded vs branded guide runs the distinction properly; the short version is to know which one you are getting, and which pharmacy prepares any compounded medication.
What separates a good programme from a cheap one
Four things, all visible before you pay:
- The medication is named — compounded or branded — and so is the pharmacy preparing any compounded dose.
- Both molecules are available, so the choice is matched to your history rather than the programme’s stock.
- A licensed clinician reviews your intake and is reachable to adjust the dose as GI side effects appear.
- The ongoing price, with medication counted in, is published as plainly as any promotional starter.
What online weight loss costs
Programmes here run from under $90 to about $250/month — Sunlight from $88, altRx from $89, LTTL from $129, MedVi around $179, and Start Willow from $249 — with Ro starting at $39 to begin. Our cost guide breaks the real monthly figure down provider by provider.
How the top-ranked providers compare
altRx and Sunlight anchor the value end with low-priced compounded plans and both molecules. Found and Start Willow lead on structured support, while Ro, TrimRx and MedVi bring established brands and promotional starts. BetterMe Rx and Lemonaid Health both carry semaglutide and tirzepatide. If you want a pill rather than an injection, our oral GLP-1 comparison ranks those separately.
Before you start treatment
GLP-1 medications commonly cause nausea and other GI effects, especially as the dose rises, and are not appropriate for everyone, including people with a personal or family history of medullary thyroid cancer, MEN 2, or pancreatitis. Disclose your full medical history and every medication and supplement you take at intake, and speak to your own doctor before starting.
More weight loss guides
- GLP-1 Weight Loss: Complete Guide to Medical Weight Management
- GLP-1 Side Effects: What to Expect and How to Prepare
- Semaglutide vs Tirzepatide: Which GLP-1 Is More Effective?
- How to Qualify for Medical Weight Loss | Eligibility Guide
- Compounded vs Brand-Name GLP-1: Complete 2026 Comparison Guide
- Medical Weight Loss Program Costs: What You Will Actually Pay
- GLP-1 Plateau: What to Do When Weight Loss Stalls
Weight Loss FAQs
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Medical Disclaimer: The content on this site is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider for medical questions, treatment decisions, or emergency care. Do not disregard professional medical advice or delay seeking it based on information found here.