Erectile dysfunction affects an estimated 30 million men in the U.S. and becomes more common with age, and the treatment landscape has expanded well beyond the traditional "blue pill." MEDVi QUAD (the four-in-one MEDVi ED treatment sometimes searched as “quad by medvi,” “medviquad,” or “mediv quad”) is a clinician-prescribed MEDVi ED medication that puts four complementary ingredients — PT-141, Sildenafil, L-Citrulline, and Tadalafil — into a single sublingual (under-the-tongue) liquid. Here's the tension I kept circling: a four-in-one formula sounds obviously better, but “more ingredients” also means more cost and a wider side-effect surface, and at $114/month for 5 doses ($179 for 10) it's a real step up from a generic. So rather than just cataloguing features, this review tries to answer when that trade is worth making — how each ingredient earns its spot, how it compares to Viagra and Cialis, and where I'd honestly steer you back to a simpler pill.
If you're already comparing ED telehealth providers, check out our full Best ED Providers comparison list to see how MEDVi QUAD ranks alongside other top options.
ExploreTreatments Editorial Rating
MEDVi QUAD, 4.6 / 5
Based on ingredients, clinical oversight, pricing, and user experience. Read our full scoring below.
10–15 min
Onset time
36 hrs
Response window
$114/mo
5 doses/month
4-in-1
Active compounds
Quick-Look Summary
| Product Name | MEDVi QUAD |
|---|---|
| Product Type | Prescription-only compounded medication |
| Delivery Method | Sublingual liquid (under the tongue) |
| Prescription Required | Yes, online intake reviewed by a licensed U.S. clinician |
| Active Ingredients | PT-141, Sildenafil, L-Citrulline, Tadalafil |
| Onset Time | As little as 10–15 minutes (individual results vary) |
| Response Window | Up to 36 hours (no automatic erection) |
| Food Interaction | Less affected by meals vs. standard oral tablets |
| Starting Price | $114/month (5 doses) · $179/month (10 doses) |
| What's Included | Consultation, prescription, medication, discreet shipping, ongoing support |
| No-Approval Policy | No charge if clinician does not approve the prescription |
What Is MEDVi QUAD?
MEDVi QUAD is a telehealth-based, prescription-only compounded medication designed to support erectile function in adult men. It's not a supplement and isn't sold over the counter, you need to complete an online medical questionnaire, which a licensed U.S. clinician reviews before any prescription is approved.
What sets it apart from conventional ED pills is its four-ingredient formula, delivered as a sublingual liquid. Rather than swallowing a tablet that must travel through the digestive system, MEDVi QUAD is absorbed directly through the tissues under the tongue, which may lead to a faster, more predictable onset.
It's aimed at men who haven't found single-ingredient tablets fully satisfying, whether that's because of inconsistent timing, reduced effectiveness with food, or a desire for a broader approach to sexual response.
How It Works: The Sublingual Advantage
Standard ED tablets are swallowed and absorbed through the gut, a process that takes time and can be slowed by food, particularly fatty meals. Sublingual delivery bypasses digestion entirely. The active compounds pass directly into the bloodstream through the mucous membranes under the tongue.
In practical terms, this means many users experience a faster onset (potentially 10–15 minutes), less variability depending on whether they've eaten, and a more consistent effect window. It's worth noting that MEDVi QUAD creates a response window, an extended period during which an erection can occur naturally with sexual stimulation, rather than producing an automatic or constant erection.
The Four Active Ingredients: What Each One Does
MEDVi QUAD earns its name from the four active ingredients it contains, each targeting a different part of the sexual response:
PT-141, Igniting Desire
Unlike the PDE5 inhibitors, PT-141 (bremelanotide) doesn't primarily act on blood vessels. Instead, it works through melanocortin receptors in the central nervous system to support the neurological and psychological side of arousal, addressing desire and mental readiness rather than just physical blood flow.
Sildenafil, Erection Firmness
The most widely recognized ED ingredient, sildenafil enhances blood flow to penile tissue to support erection quality and firmness. Decades of clinical use give it one of the strongest track records in the category.
L-Citrulline, Rapid Flow
L-Citrulline is an amino acid the body converts to L-arginine to boost nitric oxide production, relaxing blood vessels and improving circulation. In the QUAD formula, it's included to support stronger, faster blood flow that reinforces the erectile response.
Tadalafil, Extended Duration
Tadalafil is best known for its long active window, up to 36 hours, compared to other PDE5 inhibitors. Its inclusion in QUAD means the body can remain responsive for an extended period, reducing the pressure of strict timing.
MEDVi QUAD Dosage Chart: What You Actually Get Per Bottle
Anyone searching for a “MEDVi QUAD dosage chart” is usually after one of two things: how many doses come in a bottle, or the exact milligram breakdown of the four ingredients. The first has a clean answer. The second does not exist in published form, and the reason why is worth understanding before you order.
Doses per bottle, by plan
QUAD arrives as a sublingual liquid on one of two monthly plans. The smaller of the two is the one commonly searched as the “quad 5 pack”:
| Plan | Doses per bottle | Price | Per dose | Typical use pattern |
|---|---|---|---|---|
| QUAD 5-pack | 5 | $114/month | ≈ $22.80 | About once a week |
| QUAD 10-pack | 10 | $179/month | ≈ $17.90 | Two to three times a week |
Moving from five doses to ten cuts the per-dose price by roughly 21%, which is the only real volume discount on offer. Both prices are all-inclusive — consultation, compounded prescription, shipping and clinical support — and both are month-to-month, so the 5-pack is the sensible way to find out how you respond before committing to the larger bottle.
Why the milligram breakdown isn't published
QUAD is compounded, not manufactured to a fixed SKU. A licensed pharmacy prepares each order at the concentrations of PT-141, sildenafil, L-Citrulline and tadalafil that your reviewing clinician specified, drawn from what you disclosed at intake — cardiac history, current prescriptions, how you responded to any ED medication you have tried before. A generic sildenafil tablet can advertise 50 mg because every tablet in the bottle is identical; QUAD cannot, because two patients on the same $114 plan may hold bottles at different strengths.
What this means for you in practice is that the dosing sheet packed with your order is your chart, and it supersedes anything you read elsewhere. It also means a strength quoted in a forum post or a review site's “ingredients list” is describing one person's prescription, not a product spec.
Taking a dose correctly
- Dispense the prescribed amount under the tongue and let it sit for 60–90 seconds before swallowing the remainder. Swallowing it immediately defeats the sublingual route and pushes you back toward the slower absorption of a standard tablet.
- Time it roughly 10–15 minutes ahead of sexual activity. Because tadalafil stretches the response window toward 36 hours, precision here matters much less than with a 4–6 hour pill.
- One dose per 24 hours, no exceptions. Re-dosing because the first felt weak, or combining QUAD with Viagra or Cialis, adds blood-pressure risk without adding benefit.
- Food interferes less than it does with swallowed tablets, but significant alcohol still works against you — it depresses erectile function independently and compounds the hypotensive effect.
- If the dose consistently underperforms or the side effects are unpleasant, raise it with your MEDVi clinician rather than adjusting on your own. Titration is their call to make.
One caveat worth stating plainly: the FDA does not review or approve compounded drug products for safety, effectiveness, or manufacturing quality the way it does finished commercial drugs. The individual actives inside QUAD have that history; the specific blend in your bottle does not. Personalized dosing and regulatory review are, to a degree, a trade against each other, and it is worth knowing which side of that trade you are buying.
MEDVi QUAD vs. Standard Single-Ingredient ED Pills
Traditional ED medications, sildenafil, tadalafil, or vardenafil prescribed individually, are effective for many men. But they're one-dimensional by design: they target blood flow, and that's largely it. MEDVi QUAD takes a different angle by addressing multiple aspects of sexual response simultaneously.
Single-ingredient generics are less expensive and well-understood. MEDVi QUAD costs more but bundles the consultation, prescription management, compounding, and discreet delivery into a single monthly plan. For men who've already tried generic options and found them inconsistent or insufficient, the four-mechanism approach may be worth considering.
Potential Benefits
Based on the formulation and delivery method, MEDVi QUAD may offer several practical advantages for some users:
- Faster onset than traditional oral tablets, due to sublingual absorption
- Reduced dependence on meal timing for effectiveness
- A longer response window that takes the pressure off strict scheduling
- Support for both neurological arousal and desire (PT-141) and physical blood flow (PDE5 inhibitors plus L-Citrulline)
- One prescription that consolidates multiple treatment mechanisms
As with any prescription treatment, individual results vary depending on health history, dosage, and how well the body responds.
Safety, Side Effects & Medical Oversight
MEDVi QUAD is only dispensed after a licensed clinician reviews your intake. Because it's a compounded medication, prepared specifically to combine these four active ingredients, it requires a full and honest medical history from the user.
It is not appropriate for everyone. Men with certain cardiovascular conditions, those taking nitrates, or users on contraindicated medications should not use MEDVi QUAD. The online intake process is the gate for screening these risks.
Potential side effects, which vary by individual and dose, may include headaches, facial flushing, mild nausea, nasal congestion, and temporary dizziness. Many side effects, when they occur, are dose-related and can be managed with guidance from a healthcare provider.
Pros & Cons
✔ Pros
- Four-mechanism formula instead of a single ingredient
- Sublingual delivery for faster, more consistent onset
- Up to 36-hour response window reduces timing pressure
- Clinician-reviewed and medically supervised
- Discreet, plain-packaging home delivery
- No charge if not approved
✗ Cons
- Requires a prescription and medical approval
- Higher monthly cost than generic single-ingredient options
- Not suitable for all health profiles
- Limited long-term independent research on the specific combined formulation
Pricing & What's Included
MEDVi QUAD is available in two plans: $114/month for 5 doses ($22.80 per dose) or $179/month for 10 doses ($17.90 per dose). Both plans cover the online medical consultation, prescription processing, the compounded medication itself, free rush shipping, and ongoing access to clinical support.
That's meaningfully more expensive than a bottle of generic sildenafil, but the comparison isn't quite apples-to-apples. MEDVi QUAD includes the doctor's visit equivalent, compounds four prescription medications, and handles fulfillment and follow-up in one plan. Whether that bundled value justifies the premium depends on your needs and how much you've struggled with conventional options.
If clinician review determines you're not a good candidate, no charge is applied.
The Ordering Process
Getting started is straightforward. You fill out an online medical questionnaire, the kind of information a clinician needs to evaluate safety and appropriateness. A licensed U.S. clinician reviews your responses and, if approved, a prescription is processed and shipped directly to your door in unmarked packaging. There's no in-person visit required.
Who Should Consider MEDVi QUAD?
MEDVi QUAD may be a good fit for men who have tried standard single-ingredient ED medications and found results inconsistent, or those who want a formula that addresses both the physical and psychological components of sexual response. It also suits users who prefer the convenience of an online telehealth process over a traditional in-person prescription visit.
It's likely not the best starting point for someone who has never tried ED medication before (where a lower-cost generic is a reasonable first step), anyone with cardiovascular contraindications, or those who prefer the simplest and most affordable approach.
MEDVi QUAD vs Viagra vs Cialis: Full Ingredient & Pricing Comparison
Most men evaluating MEDVi QUAD are coming from one of two directions: they've already tried generic sildenafil (Viagra) or tadalafil (Cialis) and want something stronger, or they're new to ED treatment and comparing all options. Here's a direct breakdown.
MEDVi QUAD vs Viagra vs Cialis
| Feature | MEDVi QUAD | Viagra (Sildenafil) | Cialis (Tadalafil) |
|---|---|---|---|
| Active Ingredients | 4 (PT-141, Sildenafil, L-Citrulline, Tadalafil) | 1 (Sildenafil) | 1 (Tadalafil) |
| Delivery | Sublingual liquid | Oral tablet | Oral tablet |
| Onset Time | 10–15 minutes | 30–60 minutes | 30–60 minutes |
| Duration Window | Up to 36 hours | 4–6 hours | Up to 36 hours |
| Food Effect | Minimal | Reduced with fatty meals | Minimal |
| Mental Arousal Support | Yes (PT-141) | No | No |
| Monthly Cost | $114/mo (5 doses) · $179/mo (10 doses) | $20–$60 (generic) | $30–$80 (generic) |
| Telehealth Included | Yes | Separate cost | Separate cost |
The core difference is breadth. Viagra and Cialis are proven, affordable single-ingredient options, excellent first choices for most men. MEDVi QUAD targets a different group: men who have already tried PDE5 inhibitors and want faster onset, broader mechanism coverage, or more flexibility in timing. The price premium reflects that expanded capability plus the bundled telehealth service.
For a wider view of how the leading telehealth options stack up, browse our in-depth ED provider reviews, where we evaluate each service on ingredients, pricing, and clinical oversight.
Who Should NOT Use MEDVi QUAD?
MEDVi QUAD is not appropriate for everyone. The online medical intake is designed to screen for contraindications, but here are the clearest disqualifying factors:
- Men taking nitrates (nitroglycerin, isosorbide) for heart conditions, combining PDE5 inhibitors with nitrates can cause a dangerous drop in blood pressure.
- Men with certain cardiovascular conditions, recent heart attack, unstable angina, or severe heart failure require medical clearance before any ED medication.
- Men on alpha-blockers or certain antifungals/antibiotics, drug interactions can amplify side effects.
- Men with severe liver or kidney impairment, metabolism of these compounds may be affected.
- Men seeking an over-the-counter or herbal option, MEDVi QUAD is a prescription compounded medication, not a supplement.
If any of the above apply, MEDVi's intake clinician will not approve a prescription, and no charge is applied. This safeguard is a feature, not a limitation.
Also Consider: DirectMax by DirectMeds
If you are evaluating MEDVi QUAD, it is worth comparing it directly against DirectMax, another multi-ingredient compounded ED formula with a similar telehealth-first approach.
MEDVi QUAD vs. DirectMax, Side-by-Side
| Feature | MEDVi QUAD | DirectMax |
|---|---|---|
| Formula | 4-in-1 (PT-141 + Sildenafil + L-Citrulline + Tadalafil) | Triple-action (Apomorphine + Sildenafil + Tadalafil) |
| Delivery Format | Sublingual liquid (under the tongue) | Rapid dissolve tablet |
| Onset Time | 10–15 minutes | ~15 minutes |
| Duration Window | Up to 36 hours | Up to 36 hours |
| Starting Price | $114/mo (5 doses) · $179/mo (10 doses) | From $7.45/dose |
| Desire Pathway | PT-141 (peptide) | Apomorphine |
| Prescription Required | Yes | Yes |
| Best For | Men wanting the most comprehensive multi-pathway formula | Men seeking a lower per-dose cost with triple-action coverage |
MEDVi QUAD vs Rugiet Ready vs FeelGood QUAD
MEDVi QUAD is not the only 4-in-1 compounded ED formula on the market. Rugiet Ready and FeelGood QUAD are the two closest competitors, all three target men who want broader multi-ingredient coverage than single-molecule generics.
- Rugiet Ready, Combines Sildenafil, Tadalafil, and Apomorphine in a sublingual troche (wafer). Similar onset and duration to MEDVi QUAD, but uses Apomorphine for desire rather than MEDVi's PT-141, and has no L-Citrulline blood-flow booster. Popular for its troche format over liquid. Starting price comparable to MEDVi.
- FeelGood QUAD, A 4-in-1 sublingual tablet using Apomorphine, Vardenafil, Sildenafil, and Tadalafil, a different ingredient mix from MEDVi QUAD's PT-141 and L-Citrulline approach. Starts at $114/month. Ideal for those who prefer a tablet over a liquid.
- BraveRX, 3-in-1 formula (Tadalafil 15mg + Apomorphine 3mg + Sildenafil 40mg) in an oral dissolving tablet. Strong emphasis on the neurological arousal pathway via Apomorphine. Different format and dosing profile from MEDVi QUAD.
- BetterMe Rx QMAX, 4-in-1 sublingual liquid stacking three PDE5 inhibitors (Sildenafil, Tadalafil, Vardenafil) plus Apomorphine. The closest liquid alternative to MEDVi QUAD, but it leans on a third PDE5 inhibitor where MEDVi uses a PT-141 desire peptide and L-Citrulline.
MEDVi QUAD's differentiator is its liquid sublingual delivery and its combination of a PT-141 desire peptide and an L-Citrulline blood-flow booster alongside two proven PDE5 inhibitors. FeelGood QUAD is the closest priced tablet alternative at $114/month (5 doses). MEDVi's 10-dose plan at $179/month offers better per-dose value ($17.90/dose vs. $22.80/dose) for more frequent users. If you prefer a troche format, Rugiet Ready is the logical alternative to compare.
Final Verdict
Pulling it together: MEDVi QUAD is a carefully built, clinician-managed formula rather than a marketing exercise. Combining PT-141, sildenafil, L-Citrulline, and tadalafil to cover desire, firmness, blood flow, and duration in one sublingual dose is a genuinely coherent design, and the under-the-tongue delivery is a practical win for anyone tired of timing a pill around a meal.
The part I'd underline before you buy: it's not magic, and the premium over a generic is real. If you've never taken an ED medication, this is a lot of firepower for a problem a $20 script might solve on its own — start simpler and step up only if you need to. The men who get the most out of MEDVi are the ones who've already found single-ingredient tablets wanting; for them the broader formula is exactly the point, and it's a legitimate option under medical supervision.
As always, discuss any prescription ED treatment with a qualified healthcare provider before starting.
Not sure MEDVi is the right provider? Compare it against our top-rated picks on our Best ED Providers list.
Frequently Asked Questions
Is MEDVi QUAD a supplement?
No. MEDVi QUAD is a prescription-only compounded medication that requires clinician approval. It is not sold over the counter and should not be confused with herbal ED supplements.
How quickly does MEDVi QUAD work?
Because it is absorbed sublingually (under the tongue) rather than swallowed, many users report effects within 10–15 minutes. This is faster than most standard oral ED tablets, though individual timing varies based on health, dosage, and other factors.
Will MEDVi QUAD cause a constant erection?
No. MEDVi QUAD creates a response window, an erection requires natural sexual stimulation during that window. It does not cause automatic or prolonged erections (priapism risk is extremely low at prescribed doses but should be discussed with your clinician).
Does MEDVi QUAD interact with food?
Less so than standard oral tablets. Because it is absorbed under the tongue rather than through the digestive system, heavy or fatty meals have less impact on onset time and absorption compared to swallowed sildenafil or tadalafil pills.
What if I am not approved by the clinician?
If a licensed U.S. clinician reviews your intake and determines MEDVi QUAD is not appropriate for your health profile, no charge is applied. You only pay if a prescription is approved and dispensed.
How does MEDVi QUAD compare to Viagra?
Viagra (sildenafil) is a single-ingredient PDE5 inhibitor that takes 30–60 minutes orally to work and lasts 4–6 hours. MEDVi QUAD contains sildenafil plus three other active ingredients (PT-141, L-Citrulline, tadalafil) delivered sublingually, potentially working in 10–15 minutes with a 36-hour window. It is more expensive but offers a multi-mechanism approach.
How does MEDVi QUAD compare to Cialis?
Cialis (tadalafil) is a once-daily or as-needed oral tablet lasting up to 36 hours. MEDVi QUAD includes tadalafil as one of its four ingredients but adds PT-141 (desire), L-Citrulline (blood flow), and sildenafil (firmness) in a single sublingual dose. It may suit men who want broader coverage than tadalafil alone.
Is MEDVi safe to use?
MEDVi QUAD is dispensed only after a licensed clinician reviews your medical history. It is not suitable for men taking nitrates, those with certain cardiovascular conditions, or those on contraindicated medications. Common side effects include headache, flushing, nasal congestion, and mild nausea. Always disclose your full medication list during the intake process.
Can I get MEDVi QUAD without a doctor visit?
There is no in-person visit required. MEDVi operates through a fully online telehealth platform. You complete a detailed medical questionnaire, a licensed U.S. clinician reviews it, and, if approved, medication is dispensed and shipped discreetly to your door.
Does insurance cover MEDVi QUAD?
MEDVi QUAD is a compounded medication and is generally not covered by standard insurance plans. Pricing is $114/month for 5 doses or $179/month for 10 doses, and includes the consultation, prescription, medication, and shipping — no hidden fees.
How does MEDVi QUAD compare to Rugiet Ready?
MEDVi QUAD and Rugiet Ready are two of the most comparable sublingual compounded ED medications on the market. Both share Sildenafil and Tadalafil in a sublingual format with rapid onset (10–15 minutes) and a 36-hour response window. Rugiet Ready adds Apomorphine, while MEDVi QUAD pairs PT-141 for desire with an L-Citrulline blood-flow booster and is priced at $114/month for 5 doses or $179/month for 10 doses. Rugiet Ready uses a troche (sublingual wafer) rather than a liquid. The choice often comes down to preference for delivery format and which desire pathway (PT-141 vs. Apomorphine) suits your response profile.
How does MEDVi QUAD compare to FeelGood QUAD?
Both MEDVi QUAD and FeelGood QUAD are 4-in-1 compounded ED formulas, but their ingredients differ. MEDVi QUAD combines PT-141, Sildenafil, L-Citrulline, and Tadalafil, while FeelGood QUAD uses Apomorphine, Vardenafil, Sildenafil, and Tadalafil. Delivery differs too: FeelGood QUAD starts at $114/month and uses a sublingual tablet format, while MEDVi QUAD uses a liquid sublingual formula priced at $114/month for 5 doses or $179/month for 10 doses. Both are clinician-prescribed and delivered via telehealth.
Is MEDVi QUAD legitimate?
Yes. MEDVi QUAD is dispensed by a licensed U.S. compounding pharmacy and requires clinician approval before any prescription is processed. It is a legitimate prescription-only compounded medication, not a supplement or over-the-counter product. Compounded medications combine FDA-approved active ingredients into a custom formulation prepared by a licensed pharmacy. MEDVi operates through a regulated telehealth intake and does not dispense medication without clinical review.
What is the MEDVi QUAD dosage?
MEDVi QUAD dosage is determined by the prescribing clinician based on your health profile and intake responses. It is a liquid sublingual formula taken under the tongue before sexual activity. Dosing guidance, including the specific concentration of each of the four ingredients, is provided with your prescription and may be adjusted based on your response and tolerance. Do not self-adjust the dose without consulting your MEDVi clinician.
How do I cancel my MEDVi QUAD subscription?
MEDVi subscriptions can be cancelled by contacting MEDVi customer support directly. There is no long-term contract required, and the subscription is month-to-month. If you decide MEDVi QUAD is not right for you, you can cancel before the next billing cycle. Contact MEDVi through their website or the support email provided with your order confirmation.
Is MEDVi QUAD a scam?
No. Searches like "is MEDVi QUAD a scam" usually come from men who are wary of ED products sold online, but MEDVi QUAD is a prescription-only compounded medication dispensed by a licensed U.S. pharmacy only after a clinician reviews your intake. It is not an over-the-counter supplement or a fake-review "consumer reports" gimmick. The MEDVi QUAD reviews and complaints we have come across mostly concern price expectations and shipping timing, not product legitimacy, and you are only billed if a prescription is approved.
How much does MEDVi QUAD cost?
MEDVi QUAD pricing is straightforward: the 5-pack (a five-dose quad dose supply) costs $114, and the 10-pack costs $179, which lowers the per-dose price to about $17.90. That MEDVi QUAD cost includes the online consultation, the compounded prescription, discreet shipping, and ongoing clinical support, so the quad ED cost is all-inclusive rather than a per-item charge. There is no charge if the clinician does not approve you.
What are the most common MEDVi QUAD side effects?
The most commonly reported MEDVi QUAD side effects are mild and dose-related: headache, facial flushing, nasal congestion, and mild nausea. Because the formula combines two PDE5 inhibitors with PT-141 and L-Citrulline, you should disclose your full medication list during intake so the clinician can screen for interactions. MEDVi QUAD is not appropriate for men taking nitrates or those with certain cardiovascular conditions.
How many doses are in a bottle of QUAD?
The QUAD 5-pack contains 5 sublingual doses for $114/month, working out to roughly $22.80 each. The 10-pack contains 10 doses for $179/month, or about $17.90 each — a per-dose saving of around 21%. Which one you are approved for is a clinical and budget decision made during intake. Both are month-to-month with no partial refill if you run through your doses before the cycle ends.
What is the dosage for MEDVi QUAD, and is there an ingredients dosage list?
There is no published milligram list, because QUAD is compounded per patient rather than manufactured to a fixed strength. The pharmacy prepares your bottle at the PT-141, sildenafil, L-Citrulline, and tadalafil concentrations your reviewing clinician specified based on your intake, which means two men on the same plan can be on different strengths. The dosing sheet that ships with your order is the authoritative chart for your prescription, and any ingredient amounts quoted in forums or third-party listings reflect somebody else's script rather than a product specification.
How do you take MEDVi QUAD, and how long does it last?
Dispense the prescribed amount under your tongue and hold it there for about 60 to 90 seconds before swallowing what is left — swallowing immediately defeats the sublingual absorption that gives QUAD its 10 to 15 minute onset. Take it roughly 10 to 15 minutes before sexual activity, once in any 24-hour period, and never alongside another PDE5 inhibitor. The response window then runs up to about 36 hours thanks to the tadalafil component, which is a window in which an erection can occur with stimulation rather than a continuous erection.
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Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a licensed healthcare provider before starting or changing any prescription treatment. Individual results may vary.
Disclosure: ExploreTreatments.com may earn a commission if you begin treatment through links on this page, at no additional cost to you. This does not influence our editorial assessment.
About This Review
- Researched by
- Charly P., Founder and Telehealth Researcher
- Last Reviewed
- June 2026
- Disclosure
- ExploreTreatments may receive compensation from partner links. This does not influence our editorial process. Read our editorial policy.