Is MEDVi QUAD a supplement?

No. MEDVi QUAD is a prescription-only compounded medication that requires clinician approval. It is not sold over the counter and should not be confused with herbal ED supplements.

How quickly does MEDVi QUAD work?

Because it is absorbed sublingually (under the tongue) rather than swallowed, many users report effects within 10–15 minutes. This is faster than most standard oral ED tablets, though individual timing varies based on health, dosage, and other factors.

Will MEDVi QUAD cause a constant erection?

No. MEDVi QUAD creates a response window, an erection requires natural sexual stimulation during that window. It does not cause automatic or prolonged erections (priapism risk is extremely low at prescribed doses but should be discussed with your clinician).

Does MEDVi QUAD interact with food?

Less so than standard oral tablets. Because it is absorbed under the tongue rather than through the digestive system, heavy or fatty meals have less impact on onset time and absorption compared to swallowed sildenafil or tadalafil pills.

What if I am not approved by the clinician?

If a licensed U.S. clinician reviews your intake and determines MEDVi QUAD is not appropriate for your health profile, no charge is applied. You only pay if a prescription is approved and dispensed.

How does MEDVi QUAD compare to Viagra?

Viagra (sildenafil) is a single-ingredient PDE5 inhibitor that takes 30–60 minutes orally to work and lasts 4–6 hours. MEDVi QUAD contains sildenafil plus three other active ingredients (Apomorphine, L-Citrulline, tadalafil) delivered sublingually, potentially working in 10–15 minutes with a 36-hour window. It is more expensive but offers a multi-mechanism approach.

How does MEDVi QUAD compare to Cialis?

Cialis (tadalafil) is a once-daily or as-needed oral tablet lasting up to 36 hours. MEDVi QUAD includes tadalafil as one of its four ingredients but adds Apomorphine (desire), L-Citrulline (blood flow), and sildenafil (firmness) in a single sublingual dose. It may suit men who want broader coverage than tadalafil alone.

Is MEDVi safe to use?

MEDVi QUAD is dispensed only after a licensed clinician reviews your medical history. It is not suitable for men taking nitrates, those with certain cardiovascular conditions, or those on contraindicated medications. Common side effects include headache, flushing, nasal congestion, and mild nausea. Always disclose your full medication list during the intake process.

Can I get MEDVi QUAD without a doctor visit?

There is no in-person visit required. MEDVi operates through a fully online telehealth platform. You complete a detailed medical questionnaire, a licensed U.S. clinician reviews it, and, if approved, medication is dispensed and shipped discreetly to your door.

Does insurance cover MEDVi QUAD?

MEDVi QUAD is a compounded medication and is generally not covered by standard insurance plans. Pricing is $114/month for 5 doses or $179/month for 10 doses, and includes the consultation, prescription, medication, and shipping — no hidden fees.

How does MEDVi QUAD compare to Rugiet Ready?

MEDVi QUAD and Rugiet Ready are two of the most comparable sublingual compounded ED medications on the market. Both share Sildenafil, Tadalafil, and Apomorphine for desire, in a sublingual format with rapid onset (10–15 minutes) and a 36-hour response window. MEDVi QUAD adds an L-Citrulline blood-flow booster on top of that shared formula and is priced at $114/month for 5 doses or $179/month for 10 doses. Rugiet Ready starts at a similar price point and uses a troche (sublingual wafer) rather than a liquid. The choice between them often comes down to delivery format and whether the extra L-Citrulline blood-flow support is worth it to you.

How does MEDVi QUAD compare to FeelGood QUAD?

Both MEDVi QUAD and FeelGood QUAD are 4-in-1 compounded ED formulas built around the same Apomorphine desire pathway, but the fourth ingredient differs. MEDVi QUAD pairs Apomorphine, Sildenafil, and Tadalafil with an L-Citrulline blood-flow booster, while FeelGood QUAD swaps L-Citrulline for Vardenafil, a third PDE5 inhibitor. Pricing differs too: FeelGood QUAD starts at $99/month and uses a sublingual tablet format, while MEDVi QUAD uses a liquid sublingual formula priced at $114/month for 5 doses or $179/month for 10 doses. Both are clinician-prescribed and delivered via telehealth.

Is MEDVi QUAD legitimate?

Yes. MEDVi QUAD is dispensed by a licensed U.S. compounding pharmacy and requires clinician approval before any prescription is processed. It is a legitimate prescription-only compounded medication, not a supplement or over-the-counter product. Compounded medications combine FDA-approved active ingredients into a custom formulation prepared by a licensed pharmacy. MEDVi operates through a regulated telehealth intake and does not dispense medication without clinical review.

What is the MEDVi QUAD dosage?

MEDVi QUAD dosage is determined by the prescribing clinician based on your health profile and intake responses. It is a liquid sublingual formula, now formulated with Apomorphine, Sildenafil, L-Citrulline, and Tadalafil, taken under the tongue before sexual activity. Dosing guidance, including the specific concentration of each of the four ingredients, is provided with your prescription and may be adjusted based on your response and tolerance. Do not self-adjust the dose without consulting your MEDVi clinician.

How do I cancel my MEDVi QUAD subscription?

MEDVi subscriptions can be cancelled by contacting MEDVi customer support directly. There is no long-term contract required, and the subscription is month-to-month. If you decide MEDVi QUAD is not right for you, you can cancel before the next billing cycle. Contact MEDVi through their website or the support email provided with your order confirmation.

How do I buy MEDVi ED and sign up online?

You buy MEDVi ED entirely online: the MEDVi telehealth ED platform starts with a brief medical questionnaire, a licensed U.S. clinician reviews it, and — if MEDVi ED medication is appropriate — your prescription ships discreetly to your door. The MEDVi ED sign up takes only a few minutes, requires no in-person visit, and there is no charge unless a prescription is approved. MEDVi ED treatment is prescription-only, so a clinician review is always part of buying MEDVi ED online.

How much does MEDVi QUAD cost per dose?

MEDVi QUAD price works out to about $22.80 per dose on the $114 five-pack and about $17.90 per dose on the $179 ten-pack, so the quad medvi price drops as you buy more. That MEDVi QUAD cost is all-inclusive — consultation, compounded prescription, shipping, and support — rather than a separate charge for each item.

Is QUAD good for ED, and does MEDVi QUAD really work?

For the right candidate, QUAD is a strong option for ED: it pairs two proven PDE5 inhibitors (Sildenafil and Tadalafil) with Apomorphine for desire and L-Citrulline for blood flow, so it addresses more of the sexual-response cycle than a single pill. This quad ED medicine works best for men who have already tried standard ED treatment and found it inconsistent; if you have never tried an ED medication, a lower-cost generic is a sensible first step.

How many doses are in a bottle of QUAD?

Five or ten, depending on the plan your clinician approves. The $114/month plan — what people usually mean by the "MEDVi QUAD 5 pack" — includes 5 sublingual doses, which works out to about $22.80 each. The $179/month plan includes 10 doses at about $17.90 each. Both plans bundle the consultation, the compounded prescription, shipping, and clinical support, and there is no partial-refill option if you use your doses early in a cycle.

Is there a MEDVi QUAD dosage chart with exact mg strengths?

No, and that is a consequence of compounding rather than an oversight. QUAD is prepared per patient, so the concentrations of Apomorphine, sildenafil, L-Citrulline, and tadalafil are set by the reviewing clinician from your intake answers rather than sold as fixed off-the-shelf strengths. Two men on the same monthly plan can be on different concentrations. Your dosing instructions ship with the medication and are specific to your prescription — any milligram figures you find on a forum belong to somebody else's script.

How do you take MEDVi QUAD?

Place the prescribed amount of liquid under your tongue and hold it there for roughly 60 to 90 seconds before swallowing what remains, rather than swallowing it straight down. That sublingual contact time is what lets the compounds bypass the digestive tract, which is why onset can land near 10 to 15 minutes. Take it 10 to 15 minutes before sexual activity, and no more than one dose in a 24-hour period. Do not repeat a dose because the first felt weak and never stack it with Viagra, Cialis, or another PDE5 inhibitor.

How long does MEDVi QUAD last?

The response window runs up to roughly 36 hours, driven by the tadalafil component — meaningfully longer than the 4 to 6 hours typical of a sildenafil-only tablet. That window is not a continuous erection: it is a period during which an erection can occur with natural sexual stimulation. In practice it means timing matters far less than with a standard pill, since one dose can cover most of a weekend.

ED Treatment Review

MEDVi QUAD Review 2026: Does MEDVi ED Really Work?

MEDVi ED costs $114/month for 5 doses or $179 for 10 — folding four complementary compounds (Apomorphine, Sildenafil, L-Citrulline, Tadalafil) into one sublingual liquid you buy online.

4 active ingredients in one sublingual liquid dose
About $22.80/dose (5-pack) down to $17.90/dose (10-pack)
Onset in as little as 10–15 minutes; up to a 36-hour window
No charge if the clinician does not approve you

8.4

Comprehensive 4-in-1 sublingual liquid

$114/mo (5 doses) · $179/mo (10 doses)

Prescription only — a licensed U.S. clinician decides if you are eligible

By Charly P. · Not medically reviewed

Updated August 2026 · Pricing last checked August 2026

$114/mo for 5 doses
10–15 minute onset
Clinician-reviewed
No charge if not approved

Disclosure: ExploreTreatments.com may earn a commission if you begin treatment through links on this page, at no additional cost to you. This does not influence our editorial assessment.

Erectile dysfunction affects roughly 1 in 3 men over 40. MEDVi QUAD — the MEDVi telehealth ED formula you buy online — is a clinician-prescribed compounded medication that folds four complementary ingredients — Apomorphine, Sildenafil, L-Citrulline, and Tadalafil — into a single sublingual (under-the-tongue) liquid, priced at $114/month for 5 doses ($179 for 10) — meaningfully above a generic.

If you're already comparing ED telehealth providers, check out our full Best ED Providers comparison list to see how MEDVi QUAD ranks alongside other top options.

What Is MEDVi QUAD?

MEDVi QUAD is a telehealth-based, prescription-only compounded medication for erectile function in adult men — not a supplement, not sold over the counter.
You complete an online medical questionnaire, which a licensed U.S. clinician reviews before any prescription is approved.
What sets it apart from conventional ED pills: a four-ingredient formula delivered as a sublingual liquid.
Built for men who've already found single-ingredient tablets underwhelming — inconsistent timing, blunted by a heavy meal, or not covering the whole picture. If the plain pill works fine for you, MEDVi isn't solving a problem you have.

Start Your Free Medical Evaluation at MEDVi →

Quick-Look Summary

Product Name	MEDVi QUAD
Product Type	Prescription-only compounded medication
Delivery Method	Sublingual liquid (under the tongue)
Prescription Required	Yes, online intake reviewed by a licensed U.S. clinician
Active Ingredients	Apomorphine, Sildenafil, L-Citrulline, Tadalafil
Onset Time	As little as 10–15 minutes (individual results vary)
Response Window	Up to 36 hours (no automatic erection)
Food Interaction	Less affected by meals vs. standard oral tablets
Starting Price	$114/mo (5 doses) · $179/mo (10 doses)
What's Included	Consultation, prescription, medication, discreet shipping, ongoing support
No-Approval Policy	No charge if clinician does not approve the prescription

Check Your Eligibility →

How It Works: The Sublingual Advantage

Standard ED tablets are swallowed and absorbed through the gut — a process food, particularly fatty meals, can slow.
Sublingual delivery bypasses digestion entirely: the active compounds pass directly into the bloodstream through the mucous membranes under the tongue.
In practice, that means faster onset for many users (potentially 10–15 minutes), less variability depending on whether they've eaten, and a more consistent effect window.
MEDVi QUAD creates a response window — an extended period during which an erection can occur naturally with sexual stimulation — rather than an automatic or constant erection.

The Four Active Ingredients: What Each One Does

MEDVi QUAD earns its name from the four active ingredients it contains, each targeting a different part of the sexual response:

Apomorphine — Desire	Unlike PDE5 inhibitors, doesn't primarily act on blood vessels — a dopamine receptor agonist working through the central nervous system to support the neurological and psychological side of arousal. MEDVi updated QUAD to Apomorphine from its earlier PT-141 version.
L-Citrulline — Rapid Flow	An amino acid the body converts to L-arginine to boost nitric oxide production, relaxing blood vessels and improving circulation for stronger, faster blood flow.
Sildenafil — Erection Firmness	The most widely recognized ED ingredient — enhances blood flow to penile tissue for erection quality and firmness, with decades of clinical use.
Tadalafil — Extended Duration	Best known for its long active window, up to 36 hours, compared to other PDE5 inhibitors — keeps the body responsive longer and reduces the pressure of strict timing.

Per the FDA, sildenafil is approved for the treatment of erectile dysfunction in adult men.

Try the 4-in-1 Formula →

MEDVi QUAD Dosage Chart: Doses Per Bottle, Strength and How to Take It

QUAD's dosing has two halves: MEDVi publishes the dose count (what your plan buys), but not a fixed milligram strength, since QUAD is compounded per patient. It ships as a sublingual liquid in two plan sizes:

Plan	Doses included	Monthly price	Cost per dose	Best for
5-dose plan ("5 pack")	5 doses per month	$114/mo
10-dose plan	10 doses per month	$179/mo

So “how many doses in a bottle of QUAD” resolves to five or ten depending on which plan the clinician approves you for. Neither plan carries a separate consultation or shipping charge, and if you finish a month's doses early there is no partial-refill mechanism.

Why there is no published milligram chart

A compounding pharmacy prepares the formula for an individual patient at the concentrations the reviewing clinician specifies — the strength on your bottle reflects your intake answers, not a catalogue SKU.
Two men on the same $114 plan can be on different concentrations.
Because these are prescription compounds rather than a supplement, the FDA notes that compounded drug products are not FDA-approved and have not undergone premarket review for safety, effectiveness, or manufacturing quality as finished formulas — even when, as here, the individual active ingredients have.

How to take MEDVi QUAD

✓Measure the dose as prescribed and place the liquid under your tongue — not on top of it, and not swallowed straight down.
✓Hold it there for 60–90 seconds before swallowing what remains. This sublingual contact is why onset can land near 10–15 minutes.
✓Take it 10–15 minutes before sexual activity. The tadalafil component stretches the window toward 36 hours, so precise timing matters less.
✓One dose in a 24-hour period. Never stack QUAD with Viagra, Cialis, or any other PDE5 inhibitor.
✓Heavy or fatty meals matter less than with swallowed tablets, but a large amount of alcohol still works against you.
✓Dose changes go through your clinician — that is a titration conversation, not a self-adjustment.

The Ordering Process

1.
Complete the Online Questionnaire
Fill out an online medical questionnaire — the kind of information a clinician needs to evaluate safety and appropriateness. No in-person visit required.
2.
Licensed Clinician Review
A licensed U.S. clinician reviews your responses. If MEDVi QUAD is not a good fit for your health profile, no charge is applied.
3.
Discreet Delivery
If approved, your compounded prescription is processed and shipped directly to your door in unmarked packaging, with ongoing clinical support included.

Review Prescribing Details & Check Eligibility →

Pros & Cons

Pros

Four-mechanism formula instead of a single ingredient
Sublingual delivery for faster, more consistent onset
Up to 36-hour response window reduces timing pressure
Clinician-reviewed and medically supervised
Discreet, plain-packaging home delivery
No charge if not approved

Cons

Requires a prescription and medical approval
Higher monthly cost than generic single-ingredient options
Not suitable for all health profiles
Limited long-term independent research on the specific combined formulation

Pricing & What's Included

MEDVi QUAD is offered as a monthly subscription available in two plans: $114/month for 5 doses ($22.80 per dose) or $179/month for 10 doses ($17.90 per dose). Both plans cover the online medical consultation, prescription processing, the compounded medication itself, free rush shipping, and ongoing access to clinical support. If clinician review determines you're not a good candidate, no charge is applied. If a lower per-dose cost matters more to you, compare DirectMax.

See MEDVi QUAD Pricing →

Who Should Consider MEDVi QUAD?

MEDVi QUAD may be a good fit for men who have tried standard single-ingredient ED medications and found results inconsistent, want a formula that addresses both the physical and psychological components of sexual response, or prefer the convenience of an online telehealth process. It's likely not the best starting point for someone who has never tried ED medication before (where a lower-cost generic is a reasonable first step), anyone with cardiovascular contraindications, or those who prefer the simplest and most affordable approach.

Who should NOT use MEDVi QUAD: men taking nitrates (nitroglycerin, isosorbide); men with certain cardiovascular conditions (recent heart attack, unstable angina, severe heart failure); men on alpha-blockers or certain antifungals/antibiotics; men with severe liver or kidney impairment; and men seeking an over-the-counter or herbal option. If any apply, MEDVi's intake clinician will not approve a prescription, and no charge is applied.

Find Out If MEDVi QUAD Is Right for You →

How We Scored MEDVi ED

Our 8.4/10 is a weighted mean of six categories, scored in August 2026 using the same criteria we apply to every ED provider. Where we could not verify a claim, the category is capped rather than given full marks.

How We Scored It

8.4

Comprehensive 4-in-1 sublingual liquid

Formula & effectiveness(25%)8.8

A coherent four-pathway design — desire, firmness, blood flow, and duration — in one sublingual dose, though built for men the simple pill failed.

Medical safeguards(20%)8.5

Licensed U.S. clinician reviews intake and screens contraindications before any prescription; no charge if not approved.

Service & support(15%)8.5

Bundled consultation, compounding, discreet shipping, and ongoing clinical support in one month-to-month plan.

Customer experience & evidence(15%)8.0

Solid telehealth flow, but the specific compounded blend has limited independent long-term research.

Privacy & convenience(15%)8.5

Entirely online intake with discreet plain-packaging home delivery and no in-person visit.

Value & pricing(10%)7.5

A clear premium over generics; the 10-dose plan cuts per-dose cost by ~21% but it remains a step up from a $20 script.

The same weighted method is applied to every provider we score, so competitor ratings are comparable. See our best ED providers guide.

MEDVi QUAD vs Viagra vs Cialis, and the Compounded Field

Most men evaluating MEDVi QUAD are coming from one of two directions: they've already tried generic sildenafil (Viagra) or tadalafil (Cialis) and want something stronger, or they're new to ED treatment and comparing all options.

Feature	MEDVi QUAD	Viagra (Sildenafil)
Active Ingredients	4 (Apomorphine, Sildenafil, L-Citrulline, Tadalafil)	1 (Sildenafil)
Delivery	Sublingual liquid	Oral tablet
Onset Time	10–15 minutes	30–60 minutes
Duration Window	Up to 36 hours	4–6 hours
Food Effect	Minimal	Reduced with fatty meals
Mental Arousal Support	Yes (Apomorphine)	No
Monthly Cost	$114 (5 doses) · $179 (10 doses)	$20–$60 (generic)
Telehealth Included	Yes	Separate cost

The core difference is breadth. Viagra and Cialis are proven, affordable single-ingredient options, excellent first choices for most men. MEDVi QUAD targets men who have already tried PDE5 inhibitors and want faster onset, broader mechanism coverage, or more flexibility in timing.

MEDVi QUAD vs. DirectMax

Feature	MEDVi QUAD	DirectMax
Formula	4-in-1 (Apomorphine + Sildenafil + L-Citrulline + Tadalafil)	Triple-action (Apomorphine + Sildenafil + Tadalafil)
Delivery Format	Sublingual liquid (under the tongue)	Rapid dissolve tablet
Onset Time	10–15 minutes	~15 minutes
Duration Window	Up to 36 hours	Up to 36 hours
Starting Price	$114/mo (5 doses) · $179/mo (10 doses)	From $7.45/dose
Blood-Flow Booster	L-Citrulline	None
Best For	Men wanting the most comprehensive multi-pathway formula	Men seeking a lower per-dose cost with triple-action coverage

Read our full DirectMax by DirectMeds review →

MEDVi QUAD is not the only 4-in-1 compounded ED formula on the market. Rugiet Ready combines Sildenafil, Tadalafil, and Apomorphine in a sublingual troche (wafer) — the same desire pathway MEDVi QUAD now uses, but with no L-Citrulline blood-flow booster. FeelGood QUAD is a 4-in-1 sublingual tablet using Apomorphine, Vardenafil, Sildenafil, and Tadalafil, swapping MEDVi QUAD's L-Citrulline for a third PDE5 inhibitor, and BraveRX is a 3-in-1 oral dissolving tablet with a strong emphasis on the Apomorphine arousal pathway.

Top-rated ED providers we recommend:

Recommended Providers

Our editorial team’s top picks for this category.

9.9★Visit Site →

9.8★Visit Site →

9.7★Visit Site →

Safety, Side Effects & Medical Oversight

MEDVi QUAD is only dispensed after a licensed clinician reviews your intake. Because it's a compounded medication, prepared specifically to combine these four active ingredients, it requires a full and honest medical history from the user.

It is not appropriate for everyone. Men with certain cardiovascular conditions, those taking nitrates, or users on contraindicated medications should not use MEDVi QUAD. Potential side effects, which vary by individual and dose, may include headaches, facial flushing, mild nausea, nasal congestion, and temporary dizziness. Many side effects, when they occur, are dose-related and can be managed with guidance from a healthcare provider.

Frequently Asked Questions

9.9★Visit Site →

9.8★Visit Site →

9.7★Visit Site →

Still Have Questions? Start Your Evaluation →

Final Verdict

Our Editorial Take

My honest read is that MEDVi QUAD is a genuinely thought-through, clinician-managed formula, not a gimmick. Stacking Apomorphine, sildenafil, L-Citrulline, and tadalafil into one sublingual dose to hit desire, firmness, blood flow, and duration together is a coherent idea, and the sublingual delivery is a real practical edge over a pill you have to time around dinner. But I won't oversell it. It's not a cure-all, it costs more than a generic, and if you've never tried ED medication at all, starting here is paying for complexity you haven't yet found out you need. Where it clearly earns the premium is the man who's already hit the ceiling of what a single-ingredient tablet does — for him, the broader formula is the point, not the price. Match it to that situation and it's a legitimate, well-run option worth exploring under medical supervision. Overall: 8.4/10.

$114/mo for 5 doses · $179/mo for 10

Get Started with MEDVi QUAD Today →

No charge if not approved · Cancel anytime · Discreet shipping

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult a licensed healthcare provider before starting or changing any prescription treatment. Individual results may vary.

Disclosure: ExploreTreatments.com may earn a commission if you begin treatment through links on this page, at no additional cost to you. This does not influence our editorial assessment.

About This Review

Researched by: Charly P., Founder and Telehealth Researcher
Last Reviewed: August 2026
Disclosure: ExploreTreatments may receive compensation from partner links. This does not influence our editorial process. Read our editorial policy.

References

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Medical Disclaimer: The content on this site is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider for medical questions, treatment decisions, or emergency care. Do not disregard professional medical advice or delay seeking it based on information found here.